SelectFX® Alexa Fluor® 488 Peroxisome Labeling Kit, for fixed cells
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The SelectFX® Alexa Fluor® 488 Peroxisome Labeling Kit provides all the reagents needed to label the peroxisomes in fixed cells and includes cell fixative and permeabilization reagents. For detection, the kit uses a primary antibody directed against peroxisomal membrane protein 70 (PMP 70), which is a high-abundance integral-membrane component of peroxisomes, and an Alexa Fluor® 488 dye-labeled secondary antibody. The fluorescence can be observed using the same optical filters used for fluorescein.
Peroxisomes are single membrane-bound vesicles that are found in most eukaryotic cells. Their chief function is to enzymatically oxidize fatty acids and to subsequently catalyze the breakdown of H2O2, a by-product of fatty acid degradation. Recently, interest in peroxisomes has increased especially in studies related to peroxisomal origin and maintenance. Morphological abnormalities in peroxisomes related to disease states and diet have also been on the forefront of current research. The SelectFX® Alexa Fluor ® 488 Peroxisome Labeling Kit provides all the reagents needed to label the peroxisomes in fixed cells, and includes cell fixative and permeabilization reagents. For detection, the kit uses an antibody directed against peroxisomal membrane protein 70 (PMP 70), which is a high-abundance integral-membrane component of peroxisomes. PMP 70 is significantly induced by administration of hypolipidemic agents in parallel with peroxisome proliferation and the induction of peroxisomal fatty acid beta-oxidation enzymes.
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