|CD4, Mouse IgG2a monoclonal|
|Qdot® 800 nanocrystal|
Ex/Em and laser configuration:
|405 (488 or 647)/800 nm, violet, blue or red laser|
Leukocyte Workshop Status:
|Leukocyte Typing V|
Specificity for CD4
This antibody recognizes the CD4 antigen, also known as T4 and L3T4. CD4 is a cell surface receptor and a member of the immunoglobulin superfamily (IgSF). CD4 binds directly to MHC Class II molecules on the surface of antigen-presenting cells. As a co-receptor, CD4 assists the T-cell receptor (TCR) by recruiting tyrosine kinase Ick, an enzyme necessary to activate molecules involved in the signaling cascade of an activated T cell. CD4 is expressed on helper T cells, subsets of thymocytes, and to a lesser extent on peripheral blood monocytes. CD4 is also the known entry-point for HIV-1. This viral infection, which compromises the human immune system, leads to a progressive reduction of T-cells expressing CD4.
For Research Use Only
Not for use in diagnostic procedures.
Use the primary antibody selector tool to see the full list of CD4 antibodies.
You can get additional information about Qdot® nanocrystals in flow cytometry and use the Spectraviewer to help you plan your experiments. Additional general information about Life Technologies flow cytometry products and support is also available.