A member of the MAP Kinase family, MAP2K1 (mitogen-activated protein kinase kinase 1) is phosphorylated at Ser217⁄221 by a range of MAPK family members including Raf and B-Raf.
For use in combination with the Fluorescein-MAP2K1 physiological protein substrate (PV4812) to evaluate inhibitiors in medium to high throughput screening applications.