Recombinant Human Soluble TNF-Receptor Type I (sTNF-RI) is a bioactive protein intended for use in cell culture applications. sTNF-RI is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor.
• High purity
—no interference from other proteins or contaminants
• High biological activity
—more results with less protein
• Proven compatibility
—Gibco® proteins bioassayed with Gibco® mediaHigh Purity Recombinant Bioactive Protein
Recombinant Human Soluble TNF-Receptor Type I is one of more than 250 Gibco® recombinant proteins available from Life Technologies. To help ensure Gibco® growth factors are of the highest quality, each protein is analyzed for purity along with structural homogeneity to ensure a biologically active protein.High Biological Activity
In-house activity testing of Gibco® Recombinant Proteins includes cell proliferation, cytotoxicity, chemotaxis, calcium flux, secondary cytokine up-regulation, induction of surface antigen expression, antiviral, and protease assays. Recombinant Human Soluble TNF-Receptor Type I (sTNF-RI) specific activity is determined by measuring the inhibition of TNF-α mediated cytotoxicity in murine L929 cells in the presence of 0.25 ng/ml TNF-α.Proven Compatibility
Gibco® proteins are bioassayed with Gibco® media. Since 1962, Gibco® has been the consistent provider of high quality media, reagents, and sera for reliable cell culture.See our selection of recombinant Gibco® growth factors
For Research Use Only. Not intended for animal or human diagnostic or therapeutic use.