This mouse monoclonal antibody recognizes human, rat, pig, and hamster syntaxin 1A.
Specific for Syntaxin 1A
Syntaxins are a family of proteins involved in the docking of synaptic vesicles with the plasma membrane. Syntaxin, synaptobrevin, and SNAP-25 form the SNARE complex that mediates synaptic vesicle fusion and exocytosis. Binding of Munc18-1 to the N-terminus of syntaxin 1 has been demonstrated to be essential for exocytic membrane fusion (Ref 1). Decreased levels of phosphorylated syntaxin 1 in the prefrontal cortex have recently been correlated with schizophrenia (Ref 2).

For research use only. Not intended for any animal or human therapeutic or diagnostic use.

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References:

1. Khvotchev M, Dulubova I, Sun J, Dai H, Rizo J, Südhof TC. Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus. J Neurosci. 2007 Nov 7;27(45):12147-55. PubMed PMID: 17989281.
2. Castillo MA, Ghose S, Tamminga CA, Ulery-Reynolds PG. Deficits in syntaxin 1 phosphorylation in schizophrenia prefrontal cortex. Biol Psychiatry. 2010 Feb 1;67(3):208-16. Epub 2009 Sep 12. PubMed PMID: 19748077.
3. Honer WG, Hu L, Davies P. Human synaptic proteins with a heterogeneous distribution in cerebellum and visual cortex. Brain Res. 1993 Apr 23;609(1-2):9-20. PubMed PMID: 7685234.