This mouse monoclonal antibody recognizes synaptobrevin in human, pig, hamster, rat, rabbit, mouse, and bovine.
Specific for Synaptobrevin
Synaptobrevin (aka VAMP) is an integral membrane protein of synaptic vesicles that plays a major role in the formation of larger SNARE complexes, along with SNAP-25 and syntaxin. Synaptobrevin has been shown to be essential for two fast synapse-specific membrane trafficking processes: fast exocytosis for neurotransmitter release, and fast endocytosis that mediates rapid recycling of synaptic vesicles (Ref 1). Decreased levels of synaptobrevin in human hippocampus and cortex have been correlated with cognitive defects in Alzheimer's disease (Ref 2).

For research use only. Not intended for any animal or human therapeutic or diagnostic use.

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1. Deák F, Schoch S, Liu X, Südhof TC, Kavalali ET. Synaptobrevin is essential for fast synaptic-vesicle endocytosis. Nat Cell Biol. 2004 Nov;6(11):1102-8. Epub 2004 Oct 10. PubMed PMID: 15475946.
2. Sze CI, Bi H, Kleinschmidt-DeMasters BK, Filley CM, Martin LJ. Selective regional loss of exocytotic presynaptic vesicle proteins in Alzheimer's disease brains. J Neurol Sci. 2000 Apr 15;175(2):81-90. PubMed PMID: 10831767.
3. Honer WG, Hu L, Davies P. Human synaptic proteins with a heterogeneous distribution in cerebellum and visual cortex. Brain Res. 1993 Apr 23;609(1-2):9-20. PubMed PMID: 7685234.