CD72.1 (Lyb-2.1), Mouse Anti-Mouse, (PE); PE conjugated Monoclonal antibody specific to Mouse CD72. This antibody is validated for use in Flow Cytometry. Anti-CD72 recognizes the expressed product of the CD72 gene.
Murine CD72.1⁄Lyb-2.1, a type II integral membrane glycoprotein and a member of the C-lectin family of cell surface receptors, is a differentiation antigen of B cells, and is found in mouse strains expressing the Lyb-2.1 allotype. CD72.1 is the ligand of CD5 (Ly-1) which is distributed on all T cells and a small number of B cells.^1,2 The 10-1.D.2 monoclonal antibody blocks binding of CD5 to CD72 on the B cell surface, which leads to inhibition of the positive signal resulting from CD5⁄CD72 pairing.¹ However, 10-1.D.2 can itself trigger a positive signal by binding CD72.^1-5
Research Applications:
Flow cytometry ^{1, 2}
In vitro blocking and proliferation assays ^{2, 3}

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