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Ly49F, Mouse Anti-Mouse, (FITC); FITC conjugated Monoclonal antibody specific to Mouse Ly49F. This antibody is validated for use in Flow Cytometry. Anti-Ly49F recognizes the expressed product of the Ly49F gene. The monoclonal antibody HBF-719 reacts with the B6 allele of Ly49F, a member of the lectin-like homodimeric Ly49 family of cell surface receptors. Mouse Ly49 receptors exhibit allelic specificity for MHC class I Ia molecules and are thought to serve to prevent natural killer (NK) cells from attacking normal cells, while allowing them to attack infected or transformed cells in which class I molecules have been down-regulated. These inhibitory receptors are also expressed on subpopulations of mouse CD8+ T cells. The HBF-719 antibody stains ~ 11% of NK1.1+CD3- splenocytes, and 3.5% (2.5 month old) to 10.0% (11 month old) of CD8+ spleen cells from C57BL⁄6 mice.1-3
Coles, M.C., C.W. McMahon, H. Takizawa, and D.H. Raulet. 2000. Eur. J. Immunol. 30:236. Ljunggren, H.G., and K. Karre. 1990. Immunol. Today 11:237. Liu, S., and D.H. Raulet. Personal communication.
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