The CD19, clone SJ25-C1, TRI-COLOR® tandem conjugate is a monoclonal mouse antibody that recognizes the CD19 antigen. The TRI-COLOR® conjugate is a tandem R-PE-Cy®5 conjugate that permits simultaneous multicolor labeling and detection of multiple targets with excitation by a single excitation source-the 488 nm line of the argon-ion laser.


Specificity for CD19
This antibody recognizes the CD19 B cell differentiation antigen. This antigen is expressed on B cells throughout their development but is not expressed on terminally differentiated plasma cells. CD19 serves as an adapter molecule involved in B cell signaling.

Clinical Relevance
The monoclonal antibody may be used to enumerate mature B lymphocytes in human peripheral blood. Monoclonal antibodies recognizing the CD19 antigen may also be used, in combination with other indicators, for the diagnosis or prognosis of some immunodeficiency diseases. These include X-linked or Bruton’s agammaglobulinemia, common variable immunodeficiency disease (CVID), severe combined immunodeficiency disease (SCID), as well as autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. In all of these diseases, the number of peripheral blood B lymphocytes is reported to be substantially reduced. In general, diseases that exhibit decreased cellular immunocompetence may exhibit reduced numbers of CD19 mature B lymphocytes as well.

In Vitro Diagnostic
For In Vitro Diagnostic Use.

Related Links
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