|CD19, Mouse IgG1 monoclonal|
Ex/Em and laser configuration:
|488/670 nm, blue laser|
Leukocyte Workshop Status:
|Leukocyte Typing II|
Specificity for CD19
This antibody recognizes the CD19 B cell differentiation antigen. This antigen is expressed on B cells throughout their development but is not expressed on terminally differentiated plasma cells. CD19 serves as an adapter molecule involved in B cell signaling.
The monoclonal antibody may be used to enumerate mature B lymphocytes in human peripheral blood. Monoclonal antibodies recognizing the CD19 antigen may also be used, in combination with other indicators, for the diagnosis or prognosis of some immunodeficiency diseases. These include X-linked or Bruton’s agammaglobulinemia, common variable immunodeficiency disease (CVID), severe combined immunodeficiency disease (SCID), as well as autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. In all of these diseases, the number of peripheral blood B lymphocytes is reported to be substantially reduced. In general, diseases that exhibit decreased cellular immunocompetence may exhibit reduced numbers of CD19 mature B lymphocytes as well.
In Vitro Diagnostic
For In Vitro Diagnostic Use.
Use the primary antibody selector tool to see the full list of CD19 antibodies.
Use the Spectraviewer to help you plan your experiments. Additional general information about Life Technologies flow cytometry products and support is also available.