The CD4, clone S3.5, R-phycoerythrin (R-PE) conjugate is a monoclonal mouse antibody that recognizes the CD4 antigen also known as T4 and L3T4. R-PE is a stable and highly soluble phycobiliprotein that provides maximal absorbance and fluorescence emission without susceptibility to internal or external fluorescence quenching, thus providing an exceptional quantum yields and molar extinction coefficients. Use of R-PE in antibody conjugates results in probes with greatly enhanced detectability.


Specificity for CD4
This antibody recognizes the CD4 antigen also known as T4 and L3T4. CD4 serves as a co-receptor during T-cell activation through the binding of MHC Class II molecules. CD4 is also the receptor for HIV. CD4 is expressed on helper T cells, thymocyte subsets, and to a lesser extent on peripheral blood monocytes.

Clinical Relevance
The CD4 monoclonal antibody recognizes the CD4 antigen. This antibody may be used, in combination with other indicators, for the diagnosis or prognosis of immunodeficiency diseases, including hypogammaglobulinemia, severe combined immunodeficiency (SCID), and the acquired immunodeficiency disease (AIDS). The CD4 antigen is generally recognized to contain the binding site for the HIV retrovirus through interaction with the viral envelope glycoprotein. Infection of CD4+ T lymphocytes with the HIV virus eventually results in a profound depletion of these cells with the progression of disease. Infected cells continue to serve as a reservoir for the replicating virus. A decrease in the population of CD4+ cells is directly correlated with immune deficit and deterioration in infected patients.

In Vitro Diagnostic
For In Vitro Diagnostic Use.

Related Links
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