Fluorescein conjugates have been superseded by the Alexa Fluor® 488 dye conjugates, which exhibit a fluorescence emission profile almost identical to fluorescein and exhibit pH-insensitive fluorescence between pH 4 and 10. Review additional information about the CD3, Alexa Fluor® 488 dye conjugate.
|CD3, Mouse IgG2a monoclonal|
Ex/Em and laser configuration:
|488/519 nm, blue laser|
|S4.1 (also known as 7D6)|
Leukocyte Workshop Status:
|Leukocyte Typing V|
Specificity for CD3
This antibody recognizes the CD3 antigen that comprises 5 individual proteins that are responsible for T cell receptor expression and signaling. CD3 is expressed on thymocytes, T cells and some NK cells.
The CD3 monoclonal antibody recognizes the CD3 antigen. The monoclonal antibody may be used to enumerate mature T lymphocytes in human peripheral blood. The CD3 monoclonal antibody may also be used, in combination with other indicators, for the diagnosis or prognosis of some immunodeficiency diseases, including agammaglobulinemia and the severe combined immunodeficiency disease (SCID), which exhibit decreased percentages of T lymphocytes.
Decreased percentages of T lymphocytes may also be observed in some autoimmune diseases, such as systemic lupus erythematosus (SLE), multiple sclerosis, and Sjorgren's disease, as well as in certain viral diseases caused by cytomegalovirus and Epstein-Barr virus. In general, diseases that have decreased cellular immunocompetence as a component may exhibit decreases in CD3+ mature T lymphocytes.
In Vitro Diagnostic
For In Vitro Diagnostic Use.
For the full list of all CD3 antibodies available, please visit the primary antibody search tool.
Use the Spectraviewer to help you plan your experiments. Additional general information about Life Technologies flow cytometry products and support is also available.