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GeneBLAzer® CCKBR-NFAT-bla HEK293T cells contain the human Cholecystokinin Receptor B (CCKBR) stably integrated into the CellSensor® NFAT-bla HEK293T cell line. CellSensor® NFAT-bla HEK293T cells (Cat. no. K1538) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element.
The GeneBLAzer® CCKBR-NFAT-bla HEK293T cells are functionally validated for Z' and EC50 concentrations of CCK. In addition, GeneBLAzer® CCKBR-NFAT-bla HEK293T cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
Cholecystokinin (CCK) is widely distributed throughout the CNS and digestive system. Studies have shown CCKBR could be involved in anxiety, learning and memory, as well as growth of gastric mucosa.
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