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GeneBLAzer® MC5R-CRE-bla CHO-K1 cells contain the human Melanocortin Receptor 5 (MC5R) stably integrated into the CellSensor® CRE-bla CHO-K1 cell line. CellSensor® CRE-bla CHO-K1 cells (Cat. no. K1535) contain a beta-lactamase reporter gene under control of the Cyclic AMP Response Element (CRE) response element.
The GeneBLAzer® MC5R-CRE-bla CHO-K1 cells are functionally validated for Z' and EC50 concentrations of NPD-α MSH In addition, GeneBLAzer® MC5R-CRE-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
MC5R is expressed in skin, muscle, lung, liver, spleen, and adrenal tissue. MC5R is Gs-coupled and binds all of the melanocortin peptides and ACTH. A recent study suggests that MC5R is involved in fat storage in the sebocyte cells of the skin. Another study in mice links MC5R to aggressive behavior. Mice deficient in MC5R acted less aggressively when treated with alpha-MSH.
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