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GeneBLAzer® AVPR1a-NFAT-bla CHO-K1 cells contain the human Arginine Vasopressin Receptor 1a (AVPR1a) stably integrated into the CellSensor® NFAT-bla CHO-K1 cell line. CellSensor® NFAT-bla CHO-K1 cells (Cat. no. K1534) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element.
The GeneBLAzer® AVPR1a-NFAT-bla CHO-K1 cells are functionally validated for Z' and EC50 concentrations of Vasopressin. In addition, GeneBLAzer® AVPR1a-NFAT-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
The family of receptors that recognize vasopressin and oxytocin consists of four members: vasopressin receptors 1a (AVPR1a), 1b (AVPR1b), and 2 (AVPR2), and the oxytocin (OT) receptor. AVPR1a, AVPR1b, and the OT receptor couple to the Gq⁄G11 class of G proteins and trigger the release of intracellular calcium when stimulated. AVPR2 receptors couple to Gs proteins and activate adenyl cyclase. All three AVPR receptors have high affinity for their endogenous ligand, vasopressin, but AVPR1b has less affinity for oxytocin than does AVPR1a or AVPR2. The hormones vasopressin and oxytocin are synthesized in the hypothalamus. Oxytocin causes contractions in the uterus during childbirth. The main functions of arginine vasopressin (AVP) are reabsorption of water by the kidneys and contraction of smooth muscle in arteries. This system may also play a role in memory and learning.
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