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GeneBLAzer® H2-CRE-bla HEK293T cells contain the human Histamine Receptor 2 (H2) stably integrated into the CellSensor® CRE-bla HEK293T cell line. CellSensor® CRE-bla HEK293T cells (Cat. no. K1540) contain a beta-lactamase reporter gene under control of the Cyclic AMP Response Element (CRE) response element.
The GeneBLAzer® H2-CRE-bla HEK293T cells are functionally validated for Z' and EC50 concentrations of Histamine. In addition, GeneBLAzer® H2-CRE-bla HEK293T cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
The H2 receptor has been implicated in a number of disorders, including peptic ulcer disease (PUD), gastroesophageal reflux disease (GERD), dyspepsia, and stress ulcer prophylaxis.
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