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GeneBLAzer® VPAC2-CRE-bla CHO-K1 cells contain the human Vasoactive intestinal peptide⁄pituitary adenylate cyclase activating polypeptide receptor 2 (VPAC2) stably integrated into the CellSensor® CRE-bla CHO-K1 cell line. CellSensor® CRE-bla CHO-K1 cells (Cat. no. K1535) contain a beta-lactamase reporter gene under control of the Cyclic AMP Response Element (CRE) response element.
The GeneBLAzer® VPAC2-CRE-bla CHO-K1 cells are functionally validated for Z' and EC50 concentrations of VIP. In addition, GeneBLAzer® VPAC2-CRE-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
VPAC2 has been implicated in a wide range of autoimmune and inflammation disorders, including Chronic obstructive pulmonary disease, Chronic Fatigue Syndrome. VPAC2 may also play a role in Type-2 diabetes.
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