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GeneBLAzer® VPAC1-CRE-bla CHO-K1 cells contain the human Vasoactive intestinal peptide⁄pituitary adenylate cyclase activating polypeptide receptor 1 (VPAC1) stably integrated into the CellSensor® CRE-bla CHO-K1 cell line. CellSensor® CRE-bla CHO-K1 cells (Cat. no. K1535) contain a beta-lactamase reporter gene under control of the Cyclic AMP Response Element (CRE) response element.
The GeneBLAzer® VPAC1-CRE-bla CHO-K1 cells are functionally validated for Z' and EC50 concentrations of VIP. In addition, GeneBLAzer® VPAC1-CRE-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
VPAC1 has been implicated in a wide range of disorders, including Parkinson's disease, septic shock, rheumatoid arthritis, multiple sclerosis, Crohn's disease, and autoimmune diabetes. VPAC1-mediated signaling has also been shown to play a role in HIV infection.
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