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The Tango™ CNR1-bla U2OS cells contain the human Cannabinoid Receptor 1 (CNR1) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tango™ GPCR-bla U2OS parental cell line. This parental cell line stably expresses a beta-arrestin/TEV protease fusion protein and the beta-lactamase (bla) reporter gene under the control of a UAS response element.
The Tango™ CNR1 cell line has been functionally validated for Z'-factor and EC50 concentrations of CP 55,940. The CNR1 cells have been tested for assay performance under variable assay conditions. These data are available in the Validation & Assay Performance Summary in the Manuals and Brochures section.
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