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CD81, Hamster Anti-Mouse, (FITC); FITC conjugated Monoclonal antibody specific to Mouse CD81. This antibody is validated for use in Flow Cytometry. Anti-CD81 recognizes the expressed product of the CD81 gene. CD81⁄TAPA-1 is an integral membrane protein expressed on a variety of cell types, and has a high degree of sequence homology between human and mouse. CD81 is expressed on thymic stromal cells where it plays an important role in the transition of γδ+ T cells to more mature T cells with αβ T cell receptors. Immunohistochemical staining has revealed that its expression is localized to the subcapsular region of the thymus and, specifically, on cells that have distinct clustering patterns. It has been speculated that the ligand for CD81 is the pre-T cell receptor, which is composed of a TCR β chain and glycoprotein pTα. The monoclonal antibody 2F7 can block thymocyte interaction with CD81 in vitro.1-2 Research Applications: Identification and enumeration of CD81+ cells by flow cytometry Immunohistochemistry (frozen sections) Immunoprecipitation In vitro blocking of thymocyte interactions with CD81
Andria, M.L., et al. 1991. J. Immunol. 147:1030. Boismenu, R., M. Rhein, W.H. Fischer, and W.L. Harven. 1996. Science 271:198.
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