This purified mouse anti-AKT monoclonal antibody is specific to human, mouse and rat AKT. AKT monoclonal antibody recognizes the expressed product of the AKT1 gene. AKT, also known as Protein Kinase B (PKB) or RAC-α, is a serine/threonine kinase that plays an important role in multiple biological responses including metabolism, cell survival and growth by phosphorylating many proteins including GSK-3β, caspase-9, BAD, and the Forkhead Transcription Factor. A validated application for AKT monoclonal antibody is Western blotting.

Applications: Validated application for mouse anti-AKT monoclonal antibody is Western blotting.
Host species and isotype: The host species and isotype of the AKT monoclonal antibody is mouse IgG3-Kappa.
Clone ID of monoclonal antibody (mAb): The mouse anti-AKT monoclonal antibody clone is 9Q7.
Reactivity: Mouse anti-AKT monoclonal antibody detects human, mouse and rat AKT.
Product size: Mouse anti-AKT monoclonal antibody is available in a 100 µg pack size.

This monoclonal antibody recognizes a protein of 60 kDa, identified as AKT. AKT, also known as Protein Kinase B (PKB) or RAC-α, is a serine/threonine kinase that plays an important role in multiple biological responses including metabolism, cell survival and growth by phosphorylating many proteins including GSK-3β, caspase-9, BAD, and the Forkhead Transcription Factor. AKT is activated by PI3K, which in turn can interact with FAK and other cytoskeletal-associated proteins, thereby linking activation to the cytoskeleton. AKT/PKB is constitutively active in many types of human cancer, and contributes to tumor progression by promoting angiogenesis and cell invasiveness. AKT is fully activated by phosphorylation of threonine 308 by PDK1 and serine 473 by PDK2. The Reactivity of this antibody with AKT2 and AKT3 has not been tested.