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This mouse anti-PRAS40 monoclonal antibody is specific to human PRAS40. PRAS40 monoclonal antibody recognizes the expressed product of the AKT1S1 gene. PRAS40 is a 40kDa substrate of AKT. Activated AKT phosphorylates PRAS40 on threonine 246, enabling PRAS40 to bind to 14-3-3. Validated applications for PRAS40 monoclonal antibody are Western blotting and immunoprecipitation.
Applications: Validated applications for mouse anti-PRAS40 monoclonal antibody are Western blotting and immunoprecipitation. Host species and isotype: The host species and isotype of the PRAS40 monoclonal antibody is mouse IgG1-Kappa. Clone ID of monoclonal antibody (mAb): The mouse anti-PRAS40 monoclonal antibody clone is 73P21. Reactivity: Mouse anti-PRAS40 monoclonal antibody detects human PRAS40. Product size: Mouse anti-PRAS40 monoclonal antibody is available in a 100 µg pack size.
Proline-Rich AKT Substrate (PRAS40) is a 40 kDa substrate of AKT. Activated AKT phosphorylates PRAS40 on threonine 246, enabling PRAS40 to bind to 14-3-3. AKT and PRAS40 are components of the phosphoinositide 3-kinase (PI3K) pathway. This pathway plays a role in glucose uptake, cell growth, and apoptosis inhibition. The precise function of PRAS40 is not yet known; however, it has been hypothesized that PRAS40 interacts with SH3 and WW domain containing proteins, and may change the function of these proteins. In Western blot analysis with HeLa cell extracts, this antibody reacts with a 40 kDa band. This band is absent from PRAS40 siRNA-treated HeLa cell extracts.
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