This rabbit anti-Beta-Catenin polyclonal antibody is specific to human, chicken and mouse Beta-Catenin. Beta-Catenin polyclonal antibody recognizes the expressed product of the CTNNB1 gene. β-catenin appears to play an important role in the Wingless-type (Wnt) frizzled protein receptor pathway associated with cancer of the colon. Validated applications for Beta-Catenin polyclonal antibody are ELISA, immunofluorescence, Western blotting, immunoprecipitation and immunohistochemistry.
Applications: validated for ELISA, immunofluorescence, immunoprecipitation, immunohistochemistry and Western blotting
Host species and isotype: rabbit IgG
Polyclonal Antibody Designation: ZMD.323
Reactivity: human, chicken and mouse Beta-Catenin
Product size: 500 µg pack size
This antibody binds to β-catenin, a protein with Mr = 92 kDa. The catenins (α, β, and γ) are ubiquitously expressed cytoplasmic proteins that associate with E-cadherin to mediate Ca2+ dependent cell-cell adhesion, a process which is regulated by phosphorylation of protein tyrosine residues. In addition to E-cadherin, β-catenin also associates with several other proteins, including N-cadherin, the tumor suppressor gene product APC (adenomatous polyposis coli), and α-catenin. The role of the cadherins in several human cancers is currently under investigation. β-catenin appears to play an important role in the Wingless-type (Wnt) frizzled protein receptor pathway associated with cancer of the colon.