This purified rabbit anti Oligomer (A11) polyclonal antibody (pAb) recognizes the amino acid sequence-independent oligomers of proteins or peptides. A11 does not recognize monomers or mature fibers of proteins or peptides. For example, A11 reacts with soluble Aβ40 oligomers, but does not react with soluble low molecular weight Aβ40 or Aβ40 fibrils. The rabbit anti Oligomer pAb has been validated for use in dot blot, immunohistochemistry and ELISA.

Antibody Specifications:

• Applications: Validated applications for rabbit anti Oligomer (A11) polyclonal antibody are dot blot, immunohistochemistry and ELISA.
• Host Species: The host species of the Oligomer antibody is rabbit.
• Reactivity: Detects human, rat, and mouse Oligomer (A11).
• Product Size: Rabbit anti Oligomer (A11) polyclonal antibody is available in a 50 µg pack size.

This antibody recognizes amino acid sequence-independent oligomers of proteins or peptides. A11 does not recognize monomers or mature fibers of proteins or peptides. For example, A11 reacts with soluble Aβ40 oligomers, but does not react with soluble low molecular weight Aβ40 or Aβ40 fibrils. A11 recognizes oligomeric species of several other amyloidogenic polypeptides including Aβ42, human insulin, prion, polyglutamine, lysozyme, α-synuclein, and yeast prion Sup35. Many degenerative diseases are known to be related to the accumulation of misfolded proteins called, amyloid fibrils. Soluble amyloid oligomers are considered as the principal pathogenic species which play an important role in the formation of amyloid fibrils; therefore, oligomers are involved in the pathogenesis of the many neurodegenerative diseases. This anti-oligomer antibody provides a facile means of assessing the significance of oligomers in disease pathogenesis.