|Immunoprecipitation, Immunocytochemistry, In-Cell ELISA|
|Human, Rat, Mouse|
Host Species and Isotype:
|Mouse IgG1, κ|
Specific for Transitional Endoplasmic Reticulum ATPase
Transitional endoplasmic reticulum ATPase (VCP) is necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. This enzyme is involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP, and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope by similarity. This enzyme regulates E3 ubiquitin-protein ligase activity of RNF19A.
For research use only. Not intended for any animal or human therapeutic or diagnostic use.