This purified ATP synthase subunit IF1 monoclonal antibody is reactive to human, bovine, rat, and mouse. Complex V, also called F1F0ATPase or ATP synthase, is responsible for ATP production in oxidative phosphorylation, and can work in reverse as a proton pumping ATPase. This mouse anti-ATP synthase subunit IF1 monoclonal antibody can be used in validated applications such as Western blotting.

Antibody Attributes:
• Applications: Validated application for this mouse anti-ATP synthase subunit IF1 monoclonal antibody is Western blotting.
• Host Species and Isotype: The host species and isotype of the ATP synthase subunit IF1 monoclonal antibody is mouse IgG1κ.
• Clone ID of Monoclonal Antibody (mAb): This ATP synthase subunit IF1 monoclonal antibody clone is 5E2D7.
• Reactivity: This ATP synthase subunit IF1 monoclonal antibody reacts with rat, mouse, bovine, and human.
• Product Size: Mouse anti-ATP synthase subunit IF1 monoclonal antibody is available in a 100 µg pack size.

Complex V, also called F1F0ATPase, or ATP synthase, is responsible for ATP production in oxidative phosphorylation, and can work in reverse as a proton pumping ATPase. The enzyme was thought to be localized exclusively to mitochondria. However, it has recently been identified on the plasma membrane of several cell types including hepatocytes where it functions as the HDL receptor, on endothelial cells where it may act as the angiostatin receptor, and on the surface of cancer cells.

The enzyme in mammals is composed of 17 subunits, five of which make up the easily detached F1. The remainder subunits are components of two stalk domains and the proton pumping F0 part of the machinery. Two of the subunits of the F0 part are encoded on mitochondrial DNA while the other subunits are encoded by nuclear genes. Mutations in the mitochondrial-encoded subunits of ATP synthase (Complex V) cause OXPHOS disease.