The CD127, clone A7R34, PE-Cy®7 conjugate is a rat monoclonal antibody (mAb) that recognizes the CD127 antigen also known as IL-17Rα. The R-phycoerythrin (PE)-Cy®7 tandem conjugate permits simultaneous multicolor labeling and detection of multiple targets with excitation by a single excitation source - the 488 nm line of the argon-ion laser.


Specific for CD127 (IL-7Rα)
CD127 is a type I transmembrane glycoprotein that is the alpha subunit of IL-7, which forms a heterodimer with the common gamma chain (γc) receptor, also known as CD132. CD127 is expressed on common lymphoid progenitor cells, peripheral T cells, and immature B cells in the bone marrow, double-negative (CD4-/CD8-) and single-positive (CD4+ or CD8+) thymocytes; but not double-positive (CD4+/CD8+) thymocytes. CD127 is invovled in the stimulation of mature and immature T-cells as well as immature B cells proliferation and development. The rat anti-mouse CD127 (IL-7Rα) mAb has inhibited binding of IL-7 to its receptor and has been utilized in in vivo and in vitro studies of IL-7 in T and B cell development and activation.

Research Use Only
For Research Use Only. Not intended for human or animal therapeutic or diagnostic use.

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