|CD127(IL-7Rα), rat IgG2a monoclonal|
Ex/Em and laser configuration:
|488/767 nm, blue laser|
Leukocyte Workshop Status:
Specific for CD127 (IL-7Rα)
CD127 is a type I transmembrane glycoprotein that is the alpha subunit of IL-7, which forms a heterodimer with the common gamma chain (γc) receptor, also known as CD132. CD127 is expressed on common lymphoid progenitor cells, peripheral T cells, and immature B cells in the bone marrow, double-negative (CD4-/CD8-) and single-positive (CD4+ or CD8+) thymocytes; but not double-positive (CD4+/CD8+) thymocytes. CD127 is invovled in the stimulation of mature and immature T-cells as well as immature B cells proliferation and development. The rat anti-mouse CD127 (IL-7Rα) mAb has inhibited binding of IL-7 to its receptor and has been utilized in in vivo and in vitro studies of IL-7 in T and B cell development and activation.
Research Use Only
For Research Use Only. Not intended for human or animal therapeutic or diagnostic use.
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