The CD21/CD35 (CR2/CR1), clone 7E9, PE-Cy®7 conjugate is is a rat monoclonal antibody (mAb) that recognizes the shared epitope of CD21 (complement receptor 2) and CD35 (complement receptor 1). The R-phycoerythrin (PE)-Cy®7 tandem conjugate permits simultaneous multicolor labeling and detection of multiple targets with excitation by a single excitation source – the 488 nm line of the argon-ion laser.


Specific for CD21/CD35
The CD21/CD35 rat monoclonal antibody (mAb) recognizes an epitope that is shared by both CD21, also known as complement receptor 2 (CR2) and CD35, also known as complement receptor 1 (CR1). The CD21 protein binds C3d and iC3b complement fragments and acts as a receptor of Epstein-Barr virus; while the CD35 protein binds C3b, iC3b, C4b, and iC4b complement fragments. The CD21/CD35 shared epitope is primarily expressed on B lymphocytes, mast cells, follicular dendritic cells, macrophages, and activated granulocytes. It is a component of the B-cell antigen receptor complex and is involved in signal transduction.

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For Research Use Only. Not intended for human or animal therapeutic or diagnostic use.

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