The CD21/CD35 (CR2/CR1), clone 7E9, PerCP-Cy®5.5 conjugate is a rat monoclonal antibody (mAb) that recognizes the shared epitope of CD21 (complement receptor 2) and CD35 (complement receptor 1). The PerCP-Cy®5.5 tandem conjugate combines the peridinin-chlorophyll proteins (PerCP) complexes, found in nature, with the Cy®5.5 cyanine dye; thereby permitting simultaneous multicolor labeling and detection of multiple targets by utilizing a single excitation source – the 488 nm line of an argon-ion laser.


Specific for CD21/CD35
The CD21/CD35 rat monoclonal antibody (mAb) recognizes an epitope that is shared by both CD21, also known as complement receptor 2 (CR2) and CD35, also known as complement receptor 1 (CR1). The CD21 protein binds C3d and iC3b complement fragments and acts as a receptor of Epstein-Barr virus; while the CD35 protein binds C3b, iC3b, C4b, and iC4b complement fragments. The CD21/CD35 shared epitope is primarily expressed on B lymphocytes, mast cells, follicular dendritic cells, macrophages, and activated granulocytes. It is a component of the B-cell antigen receptor complex and is involved in signal transduction.

Research Use Only
For Research Use Only. Not intended for human or animal therapeutic or diagnostic use.

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