The CD14, clone Sa14-2, APC conjugate is a rat monoclonal antibody (mAb) that recognizes the CD14 antigen. APC (allophycocyanin) is one of the brightest dyes used today. It is a stable and highly soluble phycobiliprotein, which provides maximal absorbance and fluorescence without susceptibility to internal or external fluorescence quenching. APC provides almost perfect quantum efficiencies and molar extinction coefficients. Use of APC in antibody conjugates results in probes with greatly enhanced detectability.


Specific for CD14
CD14 (cluster of differentiation 14) is part of the innate immune system is involved in the clearance of gram-negative pathogens. CD14 exists in two forms. It is either anchored to the cell membrane by a glycosylphosphatidylinositol tail (GPI-linked) and called mCD14 (48 kDa) or it is a soluble protein called sCD14 (56 kDa). The mCD14 isoform is expressed on macrophages, dendritic cells, Kupffer cells, hepatocytes, and granulocytes; while the sCD14 isoform appears after cells shed mCD14 or is directly secreted from intracellular vesicles.

Research Use Only
For Research Use Only. Not intended for human or animal therapeutic or diagnostic use.

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