The CD43, clone 1B11, Alexa Fluor® 488 conjugate is a rat monoclonal antibody (mAb) that recognizes the activation-associated glycoform of CD43. Based on our testing, publications, and reported results from customers, the Alexa Fluor® 488 dye provides the best fluorescein (FITC) substitute available. The Alexa Fluor® 488 fluorescence emission profile is almost identical to that of fluorescein and it also provides pH-insensitive fluorescence between pH 4 and 10.


Specific for CD43
CD43, also known as leukosialin or sialophorin, is a large single chain type I transmembrane glycoprotein receptor. It plays roles in promoting and inhibiting cell adhesion, co-stimulating T-cell activation and survival, and inducing apoptosis in T-cells and hematopoietic progenitors. The two isoforms (CD43 115-kD glycoform and CD43 130-kD glycoform) differ with respect to the structure of their attached O-glycans. Interestingly, their expression is also mutually exclusive. CD43 115-kD glycoform is expressed on T lymphocytes, NK cells, monocytes, granulocytes, platelets, and CD5+ B cells; while CD43 130-kD glycoform is primarily expressed on myeloid cells, pre-B cells, and activated T cells. The CD43, clone 1B11, rat monoclonal antibody (mAb) recognizes the activation-associated 130-kDa glycoform.

For Research Use Only
Not intended for human or animal therapeutic or diagnostic use.

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