|CD43, rat IgG2a monoclonal|
Ex/Em and laser configuration:
|496/578 nm, blue laser|
Leukocyte Workshop Status:
Specific for CD43
CD43, also known as leukosialin or sialophorin, is a large single chain type I transmembrane glycoprotein receptor. It plays roles in promoting and inhibiting cell adhesion, co-stimulating T-cell activation and survival, and inducing apoptosis in T-cells and hematopoietic progenitors. The two isoforms (CD43 115-kD glycoform and CD43 130-kD glycoform) differ with respect to the structure of their attached O-glycans. Interestingly, their expression is also mutually exclusive. CD43 115-kD glycoform is expressed on T lymphocytes, NK cells, monocytes, granulocytes, platelets, and CD5+ B cells; while CD43 130-kD glycoform is primarily expressed on myeloid cells, pre-B cells, and activated T cells. The CD43, clone 1B11, rat monoclonal antibody (mAb) recognizes the activation-associated 130-kDa glycoform.
For Research Use Only
Not intended for human or animal therapeutic or diagnostic use.
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