The I-Ab, clone AF6-120.1, Pacific Blue™ conjugate is a mouse monoclonal antibody (mAb) that recognizes the I-Ab MHC class II alloantigen. Our Pacific Blue™ dye is optimally excited by the violet laser and conjugates of this dye are strongly fluorescent even at neutral pH. Since Pacific Blue™ and Pacific Orange™ dye conjugates can be simultaneously excited at 405 nm and emit at 455 nm and 551 nm, respectively, they conveniently facilitate two-color analysis.


Specific for I-Ab
The I-Ab mouse monoclonal antibody (mAb) reacts with the I-Ab haplotype of major histocompatibility complex (MHC) class II molecules, which are predominantly expressed on antigen presenting cells that include B lymphocytes, macrophages, dendritic cells, and certain epithelial cells. MHC Class II molecules are also expressed on a subset of T-cells from mice with the H-2b haplotype, as well as being involved in antigen presentation to T-cells expressing CD3/TCR and CD4 receptors. The I-Ab mouse mAb crossreacts with H-2k and H-2u haplotypes, but not other haplotypes (d, f, q, r, s).

For Research Use Only
Not intended for human or animal therapeutic or diagnostic use.

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