The I-A/I-E, clone M5/114.14.2, Pacific Blue™ conjugate is a rat monoclonal antibody (mAb) that recognizes the shared determinant on the I-Ab,d,q and I-Ed,k alloantigens. Our Pacific Blue™ dye is optimally excited by the violet laser and conjugates of this dye are strongly fluorescent even at neutral pH. Since Pacific Blue™ and Pacific Orange™ dye conjugates can be simultaneously excited at 405 nm and emit at 455 nm and 551 nm, respectively, they conveniently facilitate two-color analysis.


Specific for I-A/I-E
The I-A/I-E rat monoclonal antibody (mAb) reacts with the mouse major histocompatibility complex (MHC) class II I-A/I-E molecules, which are expressed on antigen presenting cells (including B cells) and a subset of T-cells from mice carrying the H-2 b, H-2 d, H-2 q, and H-2 r haplotypes. These class II molecules are involved in antigen presentation to T-cells expressing CD3/TCR and CD4 receptors.

For Research Use Only
Not intended for human or animal therapeutic or diagnostic use.

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