The CD80, clone 16-10A1, Pacific Blue™ conjugate is an Armenian hamster monoclonal antibody (mAb) that recognizes the mouse CD80 antigen. Our Pacific Blue™ dye is optimally excited by the violet laser and conjugates of this dye are strongly fluorescent even at neutral pH. Since Pacific Blue™ and Pacific Orange™ dye conjugates can be simultaneously excited at 405 nm and emit at 455 nm and 551 nm, respectively, they conveniently facilitate two-color analysis.


Specific for CD80
CD80 (cluster of differentiation 80) is a highly glycosylated member of the immunoglobulin (Ig) superfamily. CD80 is constitutively expressed on dendritic cells, monocytes, macrophages, and inducibly expressed on activated B and T cells. It is the ligand for two T-cell surface receptors. Specifically with the CD28 receptor, CD80 plays a co-stimulatory role in T-cell activation, proliferation, and cytokine production for autoregulation and intercellular association; and with the CD152 (CTLA-4) receptor, where CD80 plays an inhibitory role in T-cells for attenuation of regulation and cellular disassociation.

For Research Use Only
Not intended for human or animal therapeutic or diagnostic use.

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