|CD45, rat IgG2b monoclonal|
Ex/Em and laser configuration:
|488/767 nm, blue laser|
Leukocyte Workshop Status:
Specific for CD45
CD45, also known as protein tyrosine phosphatase receptor type C (PTPRC) and also as Leukocyte Common Antigen (LCA), exist as multiple isoforms that originate from a single complex gene. The gene contains 34 exons, where three exons of the primary transcripts are alternatively spliced to generate up to eight different mature mRNAs, which are translated into eight different isoforms. These isoforms are CD45RA, CD45RB, CD45RC, CD45RAB, CD45RAC, CD45RBC, CD45R0, CD45R (ABC). As a transmembrane tyrosine phosphatase, CD45 is expressed on all leukocytes and cells of hematopoietic origin, but not on mature erythrocytes. It is involved in signaling regulation through B and T-cell antigen receptors. The CD45 rat monoclonal antibody (mAb) recognizes all isoforms of the mouse CD45 antigen.
For Research Use Only
Not intended for human or animal therapeutic or diagnostic use.
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