The CD62L (L-selectin), clone MEL-14, PerCP-Cy^®5.5 conjugate is a rat monoclonal antibody (mAb) that recognizes mouse CD62L. The PerCP-Cy^®5.5 tandem conjugate combines the peridinin-chlorophyll proteins (PerCP) complexes, found in nature, with the Cy^®5.5 cyanine dye; thereby permitting simultaneous multicolor labeling and detection of multiple targets by utilizing a single excitation source - the 488 nm line of an argon-ion laser.


CD62L (L-Selectin)
The rat anti-mouse CD62L monoclonal antibody (mAb) reacts with CD62L (L-Selectin), a lymphocyte homing receptor that mediates initial cell adhesion interactions between circulating blood leukocytes and vascular endothelium. CD62L is expressed on most peripheral leukocytes. Relative expression levels of CD62L are often used in conjunction with other markers to distinguish naive T-cells from antigen experienced T cells. At sites of inflammation, CD62L may also play a role in circulating mononuclear leukocyte extravasation. The rat anti-mouse CD62L mAb blocks binding of lymphocytes to peripheral lymph node HEV and interferes with the migration of lymphocytes into peripheral lymph nodes in vitro. It also inhibits binding of neutrophils to lymph node venules.

Research Use Only
Not intended for human or animal therapeutic or diagnostic use.

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