|CD62L (L-selectin), Rat IgG2a monoclonal|
|PerCP-Cy®5.5 tandem dye|
Ex/Em and laser configuration:
|482/695 nm, blue laser|
Leukocyte Workshop Status:
The rat anti-mouse CD62L monoclonal antibody (mAb) reacts with CD62L (L-Selectin), a lymphocyte homing receptor that mediates initial cell adhesion interactions between circulating blood leukocytes and vascular endothelium. CD62L is expressed on most peripheral leukocytes. Relative expression levels of CD62L are often used in conjunction with other markers to distinguish naive T-cells from antigen experienced T cells. At sites of inflammation, CD62L may also play a role in circulating mononuclear leukocyte extravasation. The rat anti-mouse CD62L mAb blocks binding of lymphocytes to peripheral lymph node HEV and interferes with the migration of lymphocytes into peripheral lymph nodes in vitro. It also inhibits binding of neutrophils to lymph node venules.
Research Use Only
Not intended for human or animal therapeutic or diagnostic use.
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