The CD8a, clone 53-6.7, PerCP-Cy^®5.5 conjugate is a rat monoclonal antibody (mAb) that recognizes mouse CD8a. The PerCP-Cy^®5.5 tandem conjugate combines the peridinin-chlorophyll proteins (PerCP) complexes, found in nature, with the Cy^®5.5 cyanine dye; thereby permitting simultaneous multicolor labeling and detection of multiple targets by utilizing a single excitation source - the 488 nm line of an argon-ion laser.


CD8a
The rat anti-mouse CD8a monoclonal antibody (mAb) reacts with mouse CD8a, which is a cell surface receptor expressed as a homodimer (CD8 alpha/alpha) or as a heterodimer with the CD8 beta chain (CD8 alpha/beta). The homodimer, CD8 alpha/alpha, is expressed in dendritic cells and gamma/delta TCR T cells, which are a subpopulation of intestinal intraepithelial lymphocytes (IELs). While the heterodimer, CD8 alpha/beta, is expressed in a majority of thymocytes and a subpopulation of mature alpha/beta TCR T cells. CD8 binds to MHC class I molecules and plays a role in T-cell development and activation of mature T cells.

Research Use Only
Not intended for human or animal therapeutic or diagnostic use.

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