The CD4, clone RM4-5, PerCP-Cy^®5.5 conjugate is a rat monoclonal antibody (mAb) that recognizes CD4. The PerCP-Cy^®5.5 tandem conjugate combines the peridinin-chlorophyll protein (PerCP) complexes, found in nature, with the Cy^®5.5 cyanine dye; thereby permitting simultaneous multicolor labeling and detection of multiple targets by utilizing a single excitation source - the 488 nm line of an argon-ion laser.


CD4
The rat anti-mouse CD4 monoclonal antibody (mAb) reacts with the CD4 antigen expressed on the majority of thymocytes and on the MHC class II restricted subset of mature T cells, including Th cells. As a co-receptor in the TCR complex, CD4 is involved in T-cell activation through its interaction with MHC class II molecules on antigen presenting cells and in signal transduction via the tyrosine-protein kinase, Lck. Mouse CD4 antigen is also reported to be present on multipotential hematopoietic stem cells, bone marrow myeloid precursors, and intrathymic precursors.

Research Use Only
Not intended for human or animal therapeutic or diagnostic use.

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