The CD278 (ICOS), clone ISA-3, PE-Cy®7 conjugate is a mouse monoclonal antibody (mAb) that recognizes the human ICOS (Inducible COStimulatory molecule). The R-phycoerythrin (PE)-Cy®7 tandem conjugate permits simultaneous multicolor labeling and detection of multiple targets by utilizing a single excitation source - the 488 nm line of an argon-ion laser.

Antibody Specifications

Description:

 CD278 (ICOS), Mouse IgG1 monoclonal

Label:

 PE-Cy®7 tandem dye

Validated Application:

 Flow Cytometry

Species Reactivity:

Human

Ex/Em and laser configuration:

 488/767 nm, blue laser

Clone ID:

 ISA-3

Leukocyte Workshop Status:

NA

Regulatory Status:

RUO

CD278 (ICOS)
Mouse anti-human CD278 (ICOS) monoclonal antibody (mAb) reacts with human CD278, which is a T-cell specific activation molecule and a member of the CD28/CTLA-4 family. Human CD278 is composed of 27 kDa and 29 kDa chains. Expressed on activated T cells, it has potent co-stimulatory effect on T-cell activation and proliferation; and it is required for humoral immune responses (particularly for memory B cell and plasma cell generation). The CD278 ligand, B7h/B7RP-1, is expressed on activated antigen presenting cells and on a number of inflamed peripheral tissues.

Research Use Only
Not intended for human or animal therapeutic or diagnostic use.

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