The CD278 (ICOS), clone ISA-3, APC (allophycocyanin) conjugate is a mouse monoclonal antibody (mAb) that recognizes the ICOS (Inducible COStimulatory molecule), also known as H4/CRP- 1/AILIM. The conjugate, APC, is a stable and highly soluble phycobiliprotein which provides maximal absorbance and fluorescence without susceptibility to internal or external fluorescence quenching; thus, APC provides exceptional quantum yields, molar extinction coefficients, and greatly enhanced detectability.


CD278 (ICOS)
Mouse anti-human CD278 (ICOS) monoclonal antibody (mAb) reacts with human CD278, which is a T-cell specific activation molecule and a member of the CD28/CTLA-4 family. Human CD278 is composed of 27 kDa and 29 kDa chains. Expressed on activated T cells, it has potent co-stimulatory effect on T-cell activation and proliferation; and it is required for humoral immune responses (particularly for memory B cell and plasma cell generation). The CD278 ligand, B7h/B7RP-1, is expressed on activated antigen presenting cells and on a number of inflamed peripheral tissues.

Research Use Only
Not intended for human or animal therapeutic or diagnostic use.

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