|CD137 (4-1BB), Mouse IgG1 monoclonal|
Ex/Em and laser configuration:
|496/578 nm, blue laser|
Leukocyte Workshop Status:
The mouse anti-human CD137 (4-1BB) monoclonal antibody (mAb) reacts with human CD137, which is expressed on dendritic cells, granulocytes, mast cells, T cells, and natural killer cells. CD137 is a member of the tumor necrosis factor receptor (TNFR) family of co-stimulatory molecules; and it is involved in recruiting TNFR-associated factors (TRAF), in activating T-cells (specifically maintaining the survival of activated, CD8 memory T cells), in suppressing of myelopoiesis, and in developing dendritic cells. Ex vivo studies show that stimulating CD137 promotes expansion of CD4+CD25+ T regulatory cells. Its ligand, 4-1BBL, is found on hematopoietic stem cells, myeloid progenitor cells, activated macrophages, and mature B cells.
Research Use Only
Not intended for human or animal therapeutic or diagnostic use.
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