The CD278 (ICOS), clone C398.4A, fluorescein (FITC) conjugate is a Armenian hamster monoclonal antibody (mAb) that recognizes the ICOS (Inducible COStimulatory molecule), also known as H4/CRP- 1/AILIM, which cross-reacts with both mouse and rat ICOS. Commonly used fluorescein (FITC) conjugate provides relatively high absorptivity, excellent fluorescence quantum yield and good water solubility.


CD278 (ICOS)
Hamster anti-mouse/rat CD278 (ICOS) monoclonal antibody (mAb) cross-reacts with both mouse and rat CD278. As a member of the CD28/CTLA-4 family, CD278 is expressed on activated T-cells and has a potent co-stimulatory activity for T-cell activation and proliferation. It is required for the humoral immune response and is thought to play a protective role in inflammatory autoimmune diseases and in the development of Th2 cells. Also CD278 binds to its ligand, B7h/B7RP-1, on activated antigen presenting cells.

Research Use Only
Not intended for human or animal therapeutic or diagnostic use.

Related Links
Use the Spectraviewer to help you plan your experiments. Additional general information about Life Technologies flow cytometry products and support is also available.