The CD107a/LAMP-1 (clone H4A3) fluorescein (FITC) is a monoclonal mouse antibody that recognizes human CD107a/LAMP-1. Commonly used, fluorescein conjugates provide relatively high absorptivity, excellent fluorescence quantum yield, and good water solubility

CD107a/LAMP-1
CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated, type-I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by granulocytes, T cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium, and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The up-regulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential, where they may increase adhesion to extracellular matrix and endothelium.

For Research Use Only. Not intended for human or animal therapeutic or diagnostic use.