|Description:||CD44/Pgp-1, Mouse IgG2a|
|Validated Application:||Flow Cytometry|
|Ex/Em and laser configuration:||650/660 nm, red laser|
|Leukocyte Workshop Status:||NA|
CD44, also known as phagocytic glycoprotein-1 (Pgp-1) and the receptor for hyaluronate, exists as a large number of different isoforms resulting from alternative RNA splicing. The major isoform expressed on lymphocytes, myeloid cells and erythrocytes is a glycosylated type-I transmembrane protein. Other variable isoforms containing glycosaminoglycans have molecular weights ranging from 110 to 250 kDa and are widely expressed on hematopoietic and non-hematopoietic cells. CD44 contributes to the adhesion of leukocytes to endothelial cells, stromal cells and the extracellular matrix. It also plays a functional role in cell migration, lymphocyte homing, and adhesion during hematopoiesis and lymphocyte activation.
For Research Use Only. Not intended for human or animal therapeutic or diagnostic use.