|Description:||CD80/B7-1, Rat IgG2a monoclonal|
|Validated Application:||Flow Cytometry|
|Ex/Em and laser configuration:||496/578 nm, blue laser|
|Leukocyte Workshop Status:||NA|
CD80 (B7-1) is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is constitutively expressed by dendritic cells, monocytes, and peritoneal macrophages. Expression of CD80 on B cells is up-regulated after activation by various means, including stimulation by LPS, IL-4, and surface Ig receptor cross-linking with peak expression occurring between 48 and 72 hours post-activation. The interaction of CD80/B7-1 with its ligands CD28 and CD152/CTLA-4 provides a potent co-stimulatory signal for T cells activated through the CD3/T cell receptor complex. The monoclonal antibody 1G10 blocks binding of CTLA-4 to CD80, but it does not block stimulation of T cells by natural antigen-presenting cells.
For Research Use Only. Not intended for human or animal therapeutic or diagnostic use.