|Description:||CD16/32, Rat IgG2a monoclonal|
|Validated Application:||Flow Cytometry|
|Ex/Em and laser configuration:||488/519 nm, blue laser|
|Leukocyte Workshop Status:||NA|
The lymphocyte Fcγ receptors recognize the Fc portion of IgG, presented either as immune complexes or as free antibody. The different classes of receptors are distinguished by size, tissue distribution and affinity for IgGs. The Fc type II receptor is expressed on a wide variety of cells, including B cells, hematopoietic cells, monocyte/macrophages, neutrophils, platelets, Langerhans cells, eosinophils, basophils, trophoblasts, and endothelial cells of the placenta. The Fcγ type III receptors are of higher affinity than type II, and are expressed on macrophages, NK cells, and neutrophils. Both types of receptors can be expressed on the same cell and in varying ratios. The receptors are constitutively expressed, although cytokines and lymphokines can modulate their expression. Besides identifying FcγR+ cells, monoclonal antibodies to the FcγII/III receptor have been used to block Fc receptor binding of IgG, for Fc-mediated signal transduction and effector functions, for clearance of immune complexes, and to attenuate infection by organisms dependent on FcγR for parasitic invasion. The monoclonal antibody 93 recognizes a conformational epitope formed by FcγII and FcγIII receptors.
For Research Use Only. Not intended for human or animal therapeutic or diagnostic use.