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|Description:||CD3ε, Armenian Hamster IgG1 monoclonal|
|Validated Application:||Flow Cytometry|
|Ex/Em and laser configuration:||496/578 nm, blue laser|
|Leukocyte Workshop Status:||NA|
CD3ε is a member of the immunoglobulin superfamily of cell surface receptors, and is comprised of five invariable chains ranging in size from 16-28 kDa and is closely associated with the T-cell antigen receptor (TCR). It is expressed on all T cells of all mouse strains. CD3 plays a major role in signaling during antigen recognition, leading to T-cell activation. The 145-2C11 monoclonal antibody recognizes an epitope on the 25kD ε-chain of the CD3/TCR complex. In the presence of Fc receptor-bearing accessory cells, soluble 145-2C11 can activate primed and naive T cells in vitro. 145-2C11 can also induce redirected lysis of specific target cells by CTL clones, and can block lysis of specific target cells by antigen-specific CTL’s. Immobilized 145-2C11 can activate both normal T lymphocytes and cloned T-cell lines. Under certain conditions, T-cell activation by 145-2C11 may result in apoptotic cell death.
For Research Use Only. Not intended for human or animal therapeutic or diagnostic use.