Phospho-MEK1 (Thr 286) antibody recognizes human, monkey, mouse, and rat MEK1 phosphorylated at threonine 286 in western blot, flow cytometry, immunofluorescence, and immunoprecipitation.
MEK1, also called MAPK or Erk kinase, is a dual-specificity protein kinases that functions in a mitogen activated protein kinase cascade controlling cell growth and differentiation. MEK1 activation occurs through phosphorylation of two serine residues at positions 217 and 221 by Raf-like molecules. MEK1 is phosphorylated by cdk5 at Thr286 in mitotic cells, causing negative feedback of the p44/42 MAP kinase. The MEK1 [pThr286] Antibody detects endogenous levels of MEK1 phosphorylated at threonine 286, and does not cross-react with phosphorylated MEK2. pathway.