|Human, mouse, rat|
Host Species and Isotype:
SHC possesses SH2 and PTB domains and serves as a scaffold protein in signaling for a variety of receptor tyrosine kinases. SHC exists in p46, p52, and p66 isoforms, which are produced by using alternative translation initiation sites or a differentially spliced message (Ref 1-3). In response to extracellular signals, the SH2 and PTB domains of SHC interact with the activated receptors, leading to phosphorylation of SHC on three different tyrosine residues: Tyr239, Tyr240, and Tyr317 (Ref 4-6). GRB2/Sos binds to SHC phosphorylated at these sites, activating the Ras/Raf/ MAPK pathway (Ref 4). Both SHC expression and its tyrosine phosphorylation play an essential and nonredundant role in thymic T-cell development (Ref 7).
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