This purified recombinant human biotinylated Fab recognizes PRDM4 in human samples.

Recombinant antibody characteristics include:
• Validation in immunoprecipitation
• Superior lot-to-lot consistency
• Extremely high specificity and sensitivity
• Recombinant human biotinylated Fab
• Specific for PRDM4

PRDM4 (Positive Regulatory Domain 4) belongs to a family of zinc-finger motif transcription factors involved in cell differentiation and development. Disregulation of PRD family transcription factors results in uncontrolled cell proliferation. This protein family contains a defining conserved PR domain (a motif with lysine N-methyl transferase activity), followed by a set of zinc-finger motifs. However, only PRDM2 and PRDM9 have been shown to have methyl transferase activities. PRDM4 specifically has a PR-zinc knuckle motif followed by zinc-fingers, and has been implied in transduction of nerve growth factor signal by interacting with neurotrophin receptor and cell growth arrest. The gene is located on chromosome arm 12q23; in a region that is thought to contain tumor suppressor gene.

Exceptional Consistency Saves You Time and Money
Recombinant antibodies are produced by transfection of mammalian cells with heavy and light chain antibody cDNAs. This provides you with the highest consistency between lots, eliminating the need to revalidate your assays for each lot.

High Specificity Means More Reliable Data
The recombinant technology employed in manufacture of the antibody assures greatest degree of reliability. Staining of nonspecific proteins is virtually eliminated while very high sensitivity is achieved. Invitrogen has validated this antibody in immunoprecipitation.

High Sensitivity Lets You Detect Low Levels of Target Protein
Recombinant antibodies demonstrate much higher sensitivity than ordinary antibodies. Proteins expressed in low levels can be detected with high specificity allowing you to use less of your precious samples than with ordinary antibodies.

Recombinant mouse IgG – Use Like Any Other IgG Antibody
As with traditional IgG antibodies, gel electrophoresis of recombinant antibodies produces a 150 kDa band under non-reducing conditions and 50 kDa and 25 kDa bands under reducing conditions.

For Research Use Only. Not intended for any animal or human therapeutic or diagnostic use.

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